First, confirm that all expansion cards (including video card) have been removed from the motherboard.
On the assumption that you did, yes, there is a short on either the +12V line or the -12V line on the 5155/5160 motherboard. Or, it be both.
As you may have seen, we are daling with that siuation now with the 5155 thread started by latvija13.
On the 5155/5160 motherboard, the only devices on the +/-12V lines are capacitors.
The capacitors are:
+12V line: Capacitors C56 (10 uF tantalum) and C55.
-12V line: Capacitors C58 (10 uF tantalum) and C57.
It is the tantalums that often fail.
As ibmapc wrote, a resistance check will inform you as to which line is short. You would then remove the tantalum cap on that line, then confirm that that action removed the short.
Alternatively, you could simply cut off C56 first, see if that corrects the problem, and if not, then cut off C58.
The 5155/5160 motherboard will operate without C56/C58, but ideally, you should fit a replacement/s later for the shorted capacitor/s.