I second dreddnott. I have a "test" machine with one of those removable drive holders in a 5 1/4" floppy drive slot. I have four of the drive trays, which are loaded with different hard drives. The only one that doesn't get wiped-out on occasion is my 3.1 GB drive, loaded with MS-DOS 6.2. The drive trays or caddy don't look to have any electronics in them at all, just what looks like a Centronics connector on the outside, that is split-off inside to the normal IDE and power connectors, to connect up to the hard drive.
They come in very handy when I want to check out the lastest release of my favorite Linux or BSD distro, or if I decide I need a Windows NT or 2000 (heck, even Windows 98 ) image running, I'll put it on one of the drives.
Several years ago I tried using VMWare, running Windows NT 4 under VMWare on Linux. It worked fine, for the most part. I'm just not that keen on sharing my limited system resources between two operating systems at the same time (unless one of them is TRSDOS or CP/M, running on the Xtrs emulator!), I'd rather have the full-blown thing running in it's own computer.
Not to worry, I have a couple of "spare" computers, should I need to test more than one OS at a time! ;-)