There are no easily-solderable 5V-compatible FPGAs. Basically, you'd need a lot of level shifters and good soldering equipment. Also, the mainboard CPU can't be overridden by an ISA card, so you'd need to run a cable from the old CPU socket to the ISA card. Apart from that... it is nothing that hasn't been done before. It isn't hard, but comes with lots of practical annoyances, requires a lot of work, and needs knowledge from many different domains.
Performance improvements are limited by the bus speed, so there's not much point to having a fast CPU on the ISA card. One could also run a full system inside the FPGA while a host program providing I/O runs on the existing system. From a user's point of view, it would feel like regular emulation, and from a designer's point of view... you can do that without the existing system in the first place.
Peripherals are a different story.